Try to keep a very concentrated build. I like assassins and non-destruction mages the most. Avoid crafting until a) the game needs a raised level or b) you can't survive without (which has yet to happen to me). You never need more than 5 skills max to have a good solid build, extras just add favor. Melee, range, defensive, support, support. For some builds you can just drop the melee. In others you can go all out with only 3 skills.
One build that can't be stopped is this:
The Elder Scrolls V: Skyrim Skills Builder - IGN
Only use the skills that have perks absolutely nothing else (besides armor since DP masks count as armor). that build will never run into a destruction mages nightmare: damage scaling. Your Dremora Lords for melee and Storm Atronachs for range paired with your Fury spells will kill everyone you meet. Top it off some alteration to defend from damage and Restoration for minor heals, and I never even needed a follower. This build got retired because I ran out of things to do with it. And I never really used Enchanting much either. In fact it was nearly left out of the build when I played it not long ago.
If you want something different try that or Shadow Summoner.
Assassin with conjuration and silent casting (Illusion is a joke to grind). Full list of skills: Sneak, One-handed, Archery, Light Armor, Conjuration, and Illusion (only until you can get silent casting).
Perks:
The Elder Scrolls V: Skyrim Skills Builder - IGN
Use conjuration to summon a Bound Bow for range and Dremora Lords/Storm Thralls if you're seen. Dual-wield dagger and sword for melee combat and sneak attacks. That there doesn't even need crafting to work out to be effective.