I would make an extra save right before just in case. What mods are you looking at?
Thats what I have been doing; and so far I have had sucess with the process.
the mods ive so far installed are :
Enhanced Lights and FX by Anamorfus
Enhanced Blood Textures by dDfinder
Enhanced Distant Terrain 2 - Trudgement Day by SparrowPrince
WATER - Water And Terrain Enhancement Redux by SparrowPrince
A Quality World Map - With Roads by IcePenguin
And the one Ive tried but got rid of because I didn't like is
Real Clouds by Soolie
With Nexus's mod tool its easier then ever to install/uninstall mods, but would hate to loose savedata doing so
Im not too far into the game, as I prolly spend more time modding the game then I do playing
Thank you !