Some creatures require silver or better weapons to hit them. I don't recall for sure whether or not Scamps are of that ilk, but they could be, being Daedra.
It also sounds like your char is low level, so there will be a lot of misses. You may just need to hang in there.
You should be able to get the blight disease taken care of with a potion, at a Temple for a small donation or at an altar of the Nine Divines.
Good luck!