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So I took the suggestion to start playing from a previous save game. When I got to the Inner Sanctum again, I made it through. It sounds as if my other save game got corrupted somehow. I'm glad I finally got to progress through the end of the Dawnguard story.
I have the same problem, crashing as soon as I try to enter the Inner Sanctum, EVERY time. I even tried playing the game (through Steam) on another PC and I still crashed in the same spot. I took Bethesda's suggestions and updated graphics & audio drivers. Uninstalled and reinstalled the game...