All the places have appeal and the houses themselves have limited variety so I guess you can go by the scenery that you like. It's not like you can't travel back to pick up fish from the fishery if you need it.
We started out at Winstad Manor since it was the first I earnt. Random encounters left right and centre (Bandits, Drauger, Giants, Spiders. It just went on and on) and both the kids complained constantly about the monsters in the marsh. I wasn't too impressed with the view either to be honest. So I decided to buy a bard for the place to keep my housecarl Vladamir compny (yeah, I know, just a game but I felt guilty about leaving him on his own!) and move out.
We've just moved to Lakeview Manor. Much nicer. Fewer random encounters and the scenery is beautiful. Lovely forest and the river. We've had no trouble from the conjuror since I killed him way back before I had hearthfire and only one lot of bandits have come a callin'. The bandits down the road don't bother us at all and I'll get around to wiping them out at some stage. I deliberatly built the house with a homey feel, we have the kitchen and bedroom and it makes the place feel very warm and welcoming. I do wish I'd left the entry way as a small house rather than changing it as it felt friendlier. I left it that way with Heljarchen Hall and much prefer it in retrospect. The kids seem happier at Lakeview and I see them outside playing more often.
I've only just earnt Hel Hall and I suspect it will end up being my hunting lodge and the family will divide it's time between Lakeview and Proudspire Manor once I get it set up since I do want the kids to mingle a bit with other children. I really don't know all that much about the houses in the game so we'll have to see. I have Breezholme but rarely visit. Lydia creeps me out a bit with her bed staring and was soooo frustrating as a compnion. Two quests and I just parked her back in Whiterun and left her. Heavens knows what she gets up to in my room when I'm gone.
Just a question if anyone knows, with the extra children mod, are they all in one house or do you have to spread them out in pairs?
EDIT: No worries found the link in an earlier post. Love this Forum.
Tris / Accidental Archer and Armourer / Nord / Level 35