Just edited the original post with an update. After playing my current character to level 11 I decided on a few changes.
First, removing auto-saves has been a bad idea. I've had several game freezes which caused me to have to use a previous manual save and lose progress. I now allow auto-saves but they are only used in the event of a game freeze. If my character dies I must still revert back to the last manual save, which has to happen before resting in a bed or a bedroll.
Also, if my character dies, I now have to rest and eat for 7 days in an inn. This actually can affect the game because a week goes by. So if you had stored some items in common container they might be gone, etc. It also requires an expenditure of gold for the food. This can easily cost around 200g after a week, and given the other play restrictions this is a big deal since gold is hard to come by.
Lastly, I changed how I allow potions to be used. To me it makes no sense to poison a bow, so now I'm allowing arrows to be poisoned. Essentially, I have to decide in advance (before combat) how many arrows are poisoned and with what. Once I make that decision I can't change my mind. But this simple adjustment allows me to have multiple poison arrows available for combat if I want.
I also now allow poisoning of a weapon during combat, but it's not easy. In order to do this I have to cease all action (swinging, blocking, moving, shouting, etc.) for 10 seconds. I literally count out loud to "one thousand ten". If I'm able to do that then I can poison my weapon again. If not, tough luck.
Anyways, just wanted to provide an update for anyone using these restrictions. Have fun!