Modder ParKan has created a patch for The Witcher 3: Wild Hunt that will allow you to play as Yennefer of Vengerburg instead of Geralt. Ciri, Triss and Shani are also options….you can play as any major female in the game. She’ll move the same way Geralt does and use the same weapons.
This won’t be a perfect fit. The mod only swaps out Geralt’s rig for the woman of your choice, so she’s going to sound a bit….gruff and man-like since that part can’t really be changed. Neither can the general storyline, so at one point there will be two Yennefers or two Shanis in the same room talking to each other, while one sounds like Dr. Mrs. The Monarch. If that’s not interesting enough, just wait until Geralt starts getting intimate….
Find and download the mod here. ParKan has also made another mod you might be interested in which turns NPCs into companions that fight with you in battle. Combine the two and have a Charlie’s Angels adventure, like so: